5-Bromo-2-iodobenzaldehyde
5-Bromo-2-iodobenzaldehyde is a dihalogenated aromatic aldehyde core building block for pharmaceutical synthesis. The benzene ring bears three differentially reactive sites: iodine at C2, bromine at C5 and aldehyde group at C1.
5-Bromo-2-iodobenzaldehyde
5-Bromo-2-iodobenzaldehyde
Synonyms: 2-Iodo-5-bromobenzaldehyde
CAS No.: 689291-89-2
MDL No.: MFCD07779026
Molecular Formula: C7H4BrIO
Molecular Weight: 310.91
InChIKey: MOELYMOGQIDKNW-UHFFFAOYSA-N
SMILES: O=Cc1cc(Br)cc(I)c1
Appearance: Light golden yellow to pale yellow crystalline powder, prone to yellow discoloration and iodine precipitation under prolonged light exposure
Melting Point: 89–90 ℃
Boiling Point (760 mmHg, Predicted): 312.2±27.0 ℃
Flash Point: 142.6 ℃
Density: 2.231 g/cm³
Storage Requirements
Pack in brown light-proof sealed containers with nitrogen blanketing recommended, store at 2–8 ℃, strictly shield from UV and direct sunlight.
Store separately; do not co-store with strong alkalis, strong reductants, active metals, organic amines and peroxides to prevent dehalogenation and aldehyde side reactions.
Keep packaging fully airtight against moisture and dust; standard shelf life is 12 months.
Separate from open flames, high-temperature ovens and heat sources, maintain well ventilated and dry warehouse.
Safety Operation Guidelines
All operations must be performed in fume hoods with solvent-resistant nitrile gloves, fully enclosed chemical safety goggles and dust & organic vapor respirators.
GHS Hazard Statement: Signal word Warning; H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation), H413 (May cause long lasting harmful effects to aquatic life). Classified as Class 6.1 toxic organic intermediate, Packing Group III.
Skin contact: Rinse thoroughly with plenty of running water and detergent for 15 minutes. Eye contact: Flush eyes continuously with clean water for 15 minutes and seek immediate medical treatment. Do not induce vomiting if swallowed; seek prompt medical care.
Waste mother liquor and solid residues are halogen-containing hazardous organic waste; discharge into sewers is forbidden, deliver to qualified hazardous waste disposal institutions for dedicated treatment.
Classified as Class 6.1 toxic fine chemicals for transportation; transport under light-shielded, moisture-proof and rain-proof conditions, mixed loading with acidic, alkaline, reducing or oxidizing materials is prohibited.
Purity: ≥98% HPLC
Key intermediate for small-molecule targeted drugs: Synthesis of BTK, JAK, EGFR kinase inhibitors and anti-tumor & anti-inflammatory drug candidates.
Building block for stepwise selective coupling: Utilize reactivity difference between iodine and bromine to construct multi-substituted aromatic and fused nitrogen heterocyclic drug skeletons.
Standard substrate for organic synthesis process development: Process optimization of Suzuki, Buchwald, Sonogashira and Ullmann coupling reactions.
Raw material for fused heterocycles: Cyclization of aldehyde group to prepare bioactive molecules including quinolines, isoquinolines, benzoindoles and indolopyridines.
Synthetic intermediate for optoelectronic functional organic materials and liquid crystal monomers.
High-purity chromatographic reference standard and laboratory analytical reagent (99% high-purity grade).
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