Methyl 2-chloro-3-nitroisonicotinate
Methyl 2-chloro-3-nitroisonicotinate is a multi-substituted pyridine heterocyclic fine intermediate, formally named methyl 2-chloro-3-nitropyridine-4-carboxylate
Methyl 2-chloro-3-nitroisonicotinate
Methyl 2-chloro-3-nitroisonicotinate
Synonym: Methyl 2-chloro-3-nitropyridine-4-carboxylate
CAS No.: 1379302-09-6
MDL No.: MFCD17214977
Molecular Formula: C7H5ClN2O4
Molecular Weight: 216.58
SMILES: COC(=O)C1=C(N+[O-])C(Cl)=NC=C1
Appearance: Pale yellow to off-white crystalline solid
Melting Point: 78–82 ℃
Storage Requirements
Store in tightly sealed, inert gas-purged containers away from light at 2–8 ℃.
Store separately; prohibited to co-store with strong alkalis, strong reductants, active metals and organic amines to prevent premature substitution or reduction.
Keep packaging fully airtight against moisture and light; standard shelf life is 12 months.
Keep away from open flames, high-temperature ovens and heat sources, maintain dry and ventilated warehouse.
Safety Operation Guidelines
All operations must be carried out in well-ventilated fume hoods with nitrile acid/alkali resistant gloves, chemical safety goggles and dust respirators.
GHS Hazard Classification: Signal word Warning; Hazard Statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation).
Skin contact: Rinse thoroughly with plenty of running water and detergent for 15 minutes. Eye contact: Flush eyes continuously with clean water for 15 minutes and seek immediate medical treatment.
Do not discharge waste liquid directly into sewers; process waste mother liquor and solid residues via qualified hazardous waste disposal institutions.
Classified as general organic fine intermediate, non-dangerous goods for transportation; protect from light and moisture, mixed loading with alkaline or reducing materials is forbidden.
Purity: ≥98% HPLC
Intermediate for small-molecule targeted drugs: Synthesis of pyridine-based candidate drugs including USP30, kinase and GPCR inhibitors.
Raw material for heterocyclic building blocks: Construction of fused nitrogen heterocycles such as pyridopyrazines and imidazopyridines.
Research reagent for organic synthesis: Platform for process development involving aromatic nucleophilic substitution, nitro reduction and ester hydrolysis.
Intermediate for veterinary drugs and agricultural fungicides: Preparation of bioactive pyridine-containing agrochemical molecules.
High-purity (99% grade) chromatographic standard and analytical reference substance.
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